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    Researchers discovered that participants investing in this drug for the year, lost weight within a month and have kept the body weight off through the 56 weeks from the study. Contrave can be a combination with the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which might be made up of more than one active ingredient, which might make them more effective and safer.

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    Seizures can be a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise blood pressure levels and pulse rate, and shouldn't be used in people who have a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise hypertension and heartbeat and must not be used in patients with uncontrolled high blood pressure levels, in addition to by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients on the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

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