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  • Evidence is increasing that most addiction without exception is related to issues with the brain's reward center, specially the mesolimbic system. This area of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it one should err assisting caution and let the FDA do its job and demand some study be done so that the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on his or her medications.

    Researchers found that participants investing in this drug for the year, dropped a few pounds within 4 weeks and have kept the body weight off throughout the 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of multiple active ingredient, which might make them more effective and safer.

    Combo-pilling will be the newest fad or also the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that at the time of right now there aren't any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

    Seizures are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure level and heartrate, and shouldn't be used in people with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    Most of the combinations which are used to enhance weight reduction involve an amphetamine as well as an antidepressant. Phentermine and Prozac really are a popular combination that have been around for quite a while, and although it has been around nobody wants to truly combine the 2 and try to get FDA approval to promote it as a weight-loss pill. Right there should raise some warning flag if the greedy pharmaceutical companies don't want to be involved in combining medications and selling them something should be wrong with all the combination. In fairness there exists one weight loss combination pill that is certainly in front of the FDA now Contrave?which couples naltrexone, utilized to treat alcohol and abusing drugs, with the antidepressant bupropion (Wellbutrin, Zyban) it is often given the go ahead to move forward by an FDA advisory committee, but at the time of yet is not approved.