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  • The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided they also experience weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to quitting smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and possess at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had a typical weight loss of four.1% instead of participants who have been given placebos) throughout a 12- month period, while another study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to shed weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you ought to err to the side of caution and permit the FDA do its job and demand some study be done so that the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say anything to keep people on their medications.

    Researchers found out that participants using this drug for a year, dropped a few pounds within a month and have kept the load off throughout the 56 weeks with the study. Contrave can be a combination with the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, which might make them more potent and safer.

    Combo-pilling could be the newest fad or even better the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that since right now there are no long term prescription slimming capsules that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be authorized by the FDA.

    Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug can also raise blood pressure level and heartrate, and mustn't be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure levels, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients to the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

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