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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) of more than 27, given that they also experience weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercise. Results from a medical trial that enrolled patients without diabetes indicated that patients had a typical weight loss of four years old.1% rather than participants have been given placebos) within a 12- month period, while an outside study involving patients with diabetes type 2 symptoms had a typical weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people who go through it you need to err to the side of caution and allow the FDA do its job and demand some research be done so your public recognizes the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say anything to keep people on the medications.

    Researchers found that participants using this drug for the year, dropped excess weight within one month and have kept the weight off during the entire 56 weeks of the study. Contrave is a combination of the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which are made up of more than one active ingredient, which may make them far better and safer.

    Combo-pilling could be the newest fad or better yet the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that by right now there aren't long term prescription weight loss supplements that have been authorized by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA.

    Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure level and heart rate, and really should not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise hypertension and pulse rate and must stop used in patients with uncontrolled high hypertension, as well as by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

    Most of the combinations that are used to enhance weight-loss involve an amphetamine plus an antidepressant. Phentermine and Prozac are a popular combination which were around for quite a while, and although it has been around my own mail to truly combine the 2 and try to get FDA approval to market it as a weight-loss pill. Right there should raise some warning flags if the greedy pharmaceutical companies should not be involved in combining medications and selling them something has to be wrong with all the combination. In fairness there is certainly one weight reduction combination pill that is certainly in front of the FDA now Contrave?which couples naltrexone, employed to treat alcohol and drug addiction, with the antidepressant bupropion (Wellbutrin, Zyban) it has been given the proceed to move forward by an FDA advisory committee, but since yet will not be approved.