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  • The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) of greater than 27, provided that they also are afflicted by weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (hypertension).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that features a reduced-calorie diet and exercise, Contrave provides another treatment selection for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of 4.1% in contrast to participants who were given placebos) within a 12- month period, while a separate study involving patients with diabetes type 2 symptoms had the average weight loss of 2% over treatment with placebo at one year.

    Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it one should err along the side of caution and allow the FDA do its job and demand some investigation be done so that the public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on their own medications.

    Researchers found out that participants taking this drug for a year, lost excess weight within four weeks and have kept the weight off through the 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs that are made up of many active ingredient, which can make them far better and safer.

    Combo-pilling could be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills has become popular is the fact that as of right now there are not any long term prescription diet pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA.

    Seizures are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure and heart rate, and really should not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients towards the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

    Most of the combinations which are used to enhance weight reduction involve an amphetamine as well as an antidepressant. Phentermine and Prozac are a popular combination which were around for a long time, and although it has been around no one wants to truly combine the 2 and try to get FDA approval to showcase it as a weight reduction pill. Right there should raise some warning flags if the greedy pharmaceutical companies do not want to be involved in combining medications and selling them something have to be wrong while using combination. In fairness there exists one weight loss combination pill that is certainly in front of the FDA now Contrave?which couples naltrexone, employed to treat alcohol and abusing drugs, while using antidepressant bupropion (Wellbutrin, Zyban) it has been given the go ahead to move forward by an FDA advisory committee, but since yet has not been approved.