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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) greater than 27, given that they also suffer from weight-related medical issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder in addition to being an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie exercise and dieting, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and possess at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercising. Results from a clinical study that enrolled patients without diabetes showed that patients had a typical weight loss of 4.1% in contrast to participants who have been given placebos) throughout a 12- month period, while a different study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at one year.

    Using two separate drugs to shed weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people that go through it you ought to err to the side of caution and allow FDA do its job and demand some investigation be done in order that the public knows the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to make money and that they would say everything to keep people on his or her medications.

    Researchers found out that participants taking this drug to get a year, lost excess weight within a month and have kept the body weight off during the entire 56 weeks from the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which can be made up of many active ingredient, which might make them more efficient and safer.

    Combo-pilling is the newest fad or also the newest into the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that as of right now there are no long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA.

    Seizures really are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug also can raise blood pressure and heartrate, and shouldn't be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise hypertension and heartrate and must not be used in patients with uncontrolled high blood pressure levels, and also by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients towards the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

    Suboxone is made up of two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but if your tablet is dissolved in water and injected the naloxone will cause instant withdrawal. When suboxone is used correctly, the naloxone is destroyed inside the liver soon after uptake in the intestines and it has no therapeutic effect. Buprenorphine could be the active substance; it really is absorbed under the tongue (and through the mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I used this formulation in the event the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who may have had gastric bypass, in which the first part of the intestine is bypassed and also the stomach contents empty into a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy the place that the drug is taken up by the duodenum and transferred right to the liver through the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be used up by servings of the intestine which aren't served by the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.