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  • The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) in excess of 27, given that they also have problems with weight-related health issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and possess at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a clinical study that enrolled patients without diabetes established that patients had a normal weight loss of 4.1% rather than participants who have been given placebos) after a 12- month period, while a different study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to lose weight naturally can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people that go through it you should err on the side of caution and let the FDA do its job and demand some investigation be done so the public understands the side effects and dangers of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on their medications.

    Researchers found that participants taking this drug to get a year, dropped excess weight within a month and have kept the load off throughout the 56 weeks with the study. Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which are made up of many active ingredient, which can make them more efficient and safer.

    Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular is the fact that at the time of right now there aren't any long term prescription weight loss supplements that have been approved by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA.

    Seizures can be a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise hypertension and pulse rate, and must not be used in people who have a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise hypertension and heartrate and must not used in patients with uncontrolled high hypertension, as well as by you aren't heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients for the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    Approving a drug using this type of many potentially lethal negative effects is inconsistent with all the mission statement with the FDA. The power from the drug manufacturing lobby is blatantly evident within the approval of countless drugs requiring 'post-marketing' studies which might be clearly significant to overall drug safety inside the US.