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  • The Food and Drug Administration, FDA, has approved the drug Vivitrol for the treatment of opioid dependence as outlined by a news release by them on 10-12-2010.

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    Researchers found out that participants investing in this drug to get a year, dropped excess weight within 4 weeks and have kept the load off through the entire 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which are made up of many active ingredient, which may make them more potent and safer.

    Combo-pilling will be the newest fad or also the newest to come under scrutiny and so it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is now popular may be the fact that as of right now there are no long term prescription slimming capsules that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA.

    Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug can also raise blood pressure level and heart rate, and mustn't be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

    Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone will cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed inside liver soon after uptake through the intestines and has no therapeutic effect. Buprenorphine could be the active substance; it really is absorbed within the tongue (and during the entire mouth) but destroyed from the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I manipulate this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I also have treated addicts who may have had gastric bypass, where the first area of the intestine is bypassed and the stomach contents empty in a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy the place that the drug is taken up from the duodenum and transferred right to the liver with the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be adopted by portions of the intestine which are not served from the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.